Biografia - Prof. Antonio Secchi

Prod. Antonio Secchi Direttore Scientifico del
Progetto Trapianto di Rene

Prof. Antonio Secchi, MD

Director - Strategic Research Program on Transplantation
Associate Professor of Medicine - Vita Salute San Raffaele University
Via Olgettina 60 - 20132 Milano, Italy
tel +39/02/26432805 - fax +39/02/26437788
E-mail: antonio.secchi@hsr.it / direttorescientifico@osrtrapianti.org

Biografia

Nato il 30/11/1951 a Milano

Laurea in Medicina e Chirurgia a pieni voti, Università di Milano, 27/9/1978

Specializzazione in Fisiopatologia e Fisiokinesiterapia Respiratoria, Università di Milano

Specializzazione con Lode in Diabetologia e Malattie del Ricambio, Università di Milano

Formazione

Diploma di Maturità Classica presso il Liceo Leone XIII di Milano.

1976-1978: Allievo Interno presso la Cattedra di Clinica Medica dell'Università di Milano, diretta dal Prof. Cesare Bartorelli.

1978-1979: Medico Interno presso la Cattedra di Clinica Medica dell'Università di Milano, diretta dal Prof. Cesare Bartorelli.

1979: Tirocinio pratico Ospedaliero in Medicina Generale presso l'Ospedale San Carlo di Milano, con giudizio di Ottimo.

1979-1980: Medico Interno presso la Cattedra di Clinica Medica, Istituto San Raffaele, Università di Milano, diretta dal Prof. Guido Pozza.

1981: Borsa di studio dell'Università degli Studi di Milano, su fondi da Enti Privati, dal 1/10/1980 al 30/9/1981, presso la Cattedra di Clinica Medica VIII, con benestare del Consiglio di Facoltà a svolgere l'attività di borsista all'estero. Detta attività è stata svolta presso la Clinique de Nephrologie et des Maladies Metaboliques, INSERM 80, Hopital Ed. Herriot, Lyon, France, diretta dal Prof. J. Traeger.

1981-1982: Borsa di Studio del Governo francese presso la Clinique de Nephrologie et des Maladies Metaboliques, Hopital Ed. Herriot, Lyon, France, dal 1/10/1981 al 31/3/1982.

Research and professional experience

Past positions:
1980-1981: Fellowship at the Clinique de Nephrologie et des Maladies Metaboliques, University Claude Bernard, Hopital Edouard Herriot, Lyon, France (Prof. Jules Traeger and Prof Jean Michel Dubernard) (University of Milan Fellowship)

1981-1982: Assistent Universitaire Etranger at the Clinique de Nephrologie et des Maladies Metaboliques, University Claude Bernard, Hopital Edouard Herriot, Lyon, France (Prof. Jules Traeger and Prof Jean Michael Dubernard).

1982-1987: Registrar at the Dept. of Internal Medicine, San Raffaele Scientific Institute, University of Milan (Prof.Pozza).

1987-2002: Senior Registrar at the Dept. of Internal Medicine, San Raffaele Scientific Institute, University of Milan (1987-2000: Prof. Guido Pozza; 2000-2002: Prof Claudio Rugarli).

1987-1991: Adjunct Professor, Post-graduate school of Endocrinology and Metabolic Diseases, University of Milan.

1988-1994: Coordinator of the Study Group of the Italian Society of Diabetology «New technologies for the insulin treatment of IDDM».

1993-1996: Scientific Coordinator of the Scientific Institute San Raffaele, University of Milan.

1997-1998: Vice-President of the Study group of the European Association for the Study of Diabetes «Artificial insulin delivery systems, pancreas and islet transplantation» (AIDSPIT).

1997-2001: Councilor of the International Pancreas and Islet Transplant Association (IPITA)

1999-2000: President of the Study group of the European Association for the Study of Diabetes «Artificial insulin delivery systems, pancreas and islet transplantation» (AIDSPIT).

Vice-president of the International Pancreas and Islet Transplant Association (IPITA)

2002-2005: President of the International Pancreas and Islet Transplant Association (IPITA)

2004-2007: Coordinator of the Study Group “Immunlogy and transplantation” of the Italian Society of Diabetology.

2004-2009: Member of the Board of the Cell Transplantation Society

Present positions:
1992-present: Associate Professor of Internal Medicine, University Vita Salute San Raffaele, Milan (teaching at the School of Medicine: Emergency Medicine)

2002- present Director of the Transplant Unit at the San Raffaele Institute

Member of the following Scientific Societies:
European Society for Organ Transplantation, The Transplantation Society, Societa' Italiana di Diabetologia, European Association for the Study of Diabetes, The American Diabetes Association, International Pancreas and Islet Transplant Association (IPITA), Cell Transplant Society (CTS)

Reviewer for the following scientific journals:
American Journal of Transplantation, Lancet, Transplant International , Diabetologia, Diabetes Nutrition and Metabolism Acta Diabetologica, Diabetes Care, Il Diabete, Clinical Science, Graft, Transplantation, Diabetes, Dialysis and Transplantation.

Fields of interest:
Alternative routes of insulin administration, Artificial pancreas Immunosuppressive therapy at the onset of IDDM, Kidney, panceas and islet transplantation

Scientific production (as Aug 2009):
- 176 full papers in journals reported by the Current Content, Life Science (total Impact Factor: 653)

- more than 500 presentations at International Congresses

- 58 chapters of books

Publications (last 3 years):
E Orsenigo, P. Fiorina, G Dell’Antonio, M Cristallo, C Socci, L Invernizzi, P Maffi, A Secchi, C Staudacher (2005) Gastrointestinal bleeding from enterically drained transplanted pancreas Transplant International, 18: 296-302

Venturini M, Fiorina P, Maffi P, et al. (2006) Early increase of retinal blood flow velocities at color doppler imaging in brittle type 1 diabetes after islet transplant alone. Transplantation 81(9):1274-1277.

Mercalli A, Sordi V, Ponzoni M, Maffi P, De TAddeo F, Gatti G, Servida P, Bernardi M, Bellio L, Bertuzzi F, Secchi A, Bonifacio E, Piemonti L (2006) Rapamycin induces a paspase-independent cel death in human monocytes Am. J. Transplant; 6: 1331-1341

Marzorati S, Antonioli B, Nano R, Maffi P, Piemonti L, Giliola C, Secchi A, Lakey JR, Bertuzzi F.(2006) Culture medium modulates proinflammatory conditions of human pancreatic islets before transplantation. Am J Transplant. 2006 Nov;6(11):2791-5

A.M. James Shapiro, M.D., Ph.D., Camillo Ricordi, M.D., Bernhard J. Hering, M.D., Hugh Auchincloss, M.D., Robert Lindblad, M.D., R. Paul Robertson, M.D., Antonio Secchi, M.D., et al (2006) International Trial of the Edmonton protocol for Islet Transplantation N Engl J Med 2006; 355: 1318-1330.

Paolo Fiorina, GL Perseghin, F De Cobelli, C Gremizzi, A Petrelli, L Monti, P Maffi, L Luzi, A Secchi, A del Maschio (2007). Altered Kidney Graft High-Energy Phosphate Metabolism in Kidney- Transplanted End-Stage Renal Disease Type 1 Diabetic Patients: A cross-sectional analysis of the effect of kidney alone and kidney-pancreas transplantation. Diabetes Care 30: 597– 603

Paola Maffi; Federico Bertuzzi; Francesca De Taddeo; Paola Magistretti; Rita Nano, Paolo Fiorina; Andrea Caumo, Paolo Pozzi; Carlo Socci; Massimo Venturini; Alessandro Del Maschio, Antonio Secchi MD. (2007) Kidney Function after Islet Transplant Alone in Type 1 Diabetes: Impact of immunosuppressive therapy on progression of diabetic nephropathy. Diabetes Care 2007, 30: 1150-55

Del Carro Ubaldo; Fiorina Paolo; Amadio Stefano; De Toni Franceschini Luisa; Petrelli Alessandra; Menini Stefano; Ferrari Stefania; Martinelli Boneschi Filippo; Pugliese Giuseppe; Maffi Paola; Comi Giancarlo; Secchi Antonio (2007) Evaluation of polyneuropathy markers in type 1 diabetic kidney-transplant patients and effects of isltes transplantation: neurophysiological and skin biopsy longitudinal analysis Diabetes Care. 2007 Dec;30(12):3063-9

Fiorina P, Secchi A. (2007) Pancreatic islet cell transplant for treatment of diabetes. Endocrinol Metab Clin North Am. 2007 Dec;36(4):999-1013

Orsenigo E, Casiraghi T, Socci C, Zuber V, Caldara R, Secchi A, Staudacher C. (2007) Impact of recipient and donor ages on patient and graft survival after kidney transplantation. Transplant Proc. 2007 Jul-Aug;39(6):1830-2.

Oliari AC, Caldara R, Socci C,Sordi V, Cagni N,Moretti MP, Dell’Acqua A, Mercalli A,Scavini M, Secchi A, Bonifacio E,Bosi E,Piemonti L(2008) High levels of Donor CCL2/MCP-1 predict graft-related complications and poor graft survival after kidney-pancreas transplantation Am J transplant 2008;8:1303-11

Monti P, Scirpoli M, Maffi P, Ghidoli N, De Taddeo F, Bertuzzi F, Piemonti L, Falcone M, Secchi A, Bonifacio E. (2008) Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells. J Clin Invest. 2008 May;118(5):1625-8.

Caumo A, Maffi P, Nano R, Bertuzzi F, Luzi L, Secchi A, Bonifacio E, Piemonti L.

(2008) Transplant estimated function: a simple index to evaluate beta-cell secretion after islet transplantation.

Diabetes Care. 2008 Feb;31(2):301-5.

Monti P, Scirpoli M, Maffi P, Piemonti L, Secchi A, Bonifacio E, Roncarolo MG, Battaglia M.(2008) Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T cells. Diabetes. 2008 Jun 16

Secchi et al (2008) Beta-cell transplantation for diabetes therapy. Lancet. 2008 Jul 5;372(9632):28-9

Battezzati A, Benedini S, Sereni LP, Detaddeo F, Maffi P, Secchi A, Luzi L (2008) Protein and glutamine kinetics during counter-regulatory failure in type 1 diabetes. Nutr Metab Cardiovasc Dis. 2008 Aug 5.

Monti P, Scirpoli M, Maffi P, Piemonti L, Secchi A, Bonifacio E, Roncarolo MG, Battaglia M. (2008) Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T cells. Diabetes. 2008 Jun 16.

Fiorina P, Vergani A, Petrelli A, D'Addio F, Monti L, Abdi R, Bosi E, Maffi P, Secchi A. (2008) Metabolic and immunological features of the failing islet-transplanted patient. Diabetes Care. 2008 Mar;31(3):436-8

P. Fiorina, AMJ Shapiro, C Ricorsi, A Secchi, (2008) The clinical impact of islet transplantation, Am J Transplant 2008; 8: 1990-1997

T. Berney, A. Secchi (2009) rapamycin inislet transplantation: friend or foe?, Transplant International 2009; 22: 153-161

Giuliana Cighetti, Isabella Fermo, Caroline S. Aman, Monica Ferraroni, Antonio Secchi, Paolo Fiorina, Rita Paroni (2009) Dimethylarginines in complicated type 1 diabetes: Roles of insulin, glucose, and oxidative stress, Free Radical Biology & Medicine 47 (2009) 307–311

Maria Luisa Malosio, Antonio Esposito, Anna Poletti, Sara Chiaretti, Lorenzo Piemonti, Raffaella Melzi, Rita Nano, Fabio Tedoldi, Tamara Canu, Paolo Santambrogio, Sonia Levi, Francesco De Cobelli, Paola Maffi, Antonio Secchi, and Alessandro Del Maschio .(2009) Improving the procedure for detection of intrahepatic islets by magnetic resonance imaging, Am J Transpl 2009; 9: 1-11



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